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H James Harwood Selected Research

Acetyl-CoA Carboxylase

1/2019Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.
1/2017Acetyl-coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double-blind, crossover study.
10/2016Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models.
3/2016Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
4/2005Treating the metabolic syndrome: acetyl-CoA carboxylase inhibition.
3/2004Acetyl-CoA carboxylase inhibition for the treatment of metabolic syndrome.
9/2003Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals.

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H James Harwood Research Topics

Disease

5Obesity
03/2016 - 12/2006
5Dyslipidemias (Dyslipidemia)
03/2016 - 03/2005
5Metabolic Syndrome (Dysmetabolic Syndrome X)
07/2012 - 09/2003
4Neoplasms (Cancer)
01/2019 - 12/2006
4Inflammation (Inflammations)
01/2017 - 06/2010
3Atherosclerosis
08/2011 - 01/2006
2Fatty Liver
01/2017 - 03/2016
2Insulin Resistance
03/2016 - 06/2010
2Type 2 Diabetes Mellitus (MODY)
07/2012 - 06/2010
2Hyperplasia
05/2012 - 01/2006
2Hyperglycemia
08/2011 - 06/2010
2Body Weight (Weight, Body)
10/2010 - 06/2010
2Hyperlipidemias (Hyperlipidemia)
10/2003 - 07/2002
1Hepatocellular Carcinoma (Hepatoma)
01/2019
1Non-alcoholic Fatty Liver Disease
01/2017
1Fibrosis (Cirrhosis)
01/2017
1Overweight
01/2017
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2016
1Weight Gain
03/2016
1Coronary Disease (Coronary Heart Disease)
07/2012
1Vascular Diseases (Vascular Disease)
08/2011
1Gliosis
02/2008
1Mycoses (Diseases, Fungus)
03/2007
1Infections
12/2006

Drug/Important Bio-Agent (IBA)

7Acetyl-CoA CarboxylaseIBA
01/2019 - 09/2003
7Fatty Acids (Saturated Fatty Acids)IBA
01/2017 - 09/2003
5LipidsIBA
05/2012 - 03/2005
4IsoenzymesIBA
03/2016 - 09/2003
3Pharmaceutical PreparationsIBA
10/2016 - 12/2006
3AdiponectinIBA
07/2012 - 06/2010
3Lipoproteins (Lipoprotein)IBA
05/2012 - 01/2006
3Insulin (Novolin)FDA Link
05/2012 - 01/2006
3CholesterolIBA
08/2011 - 02/2008
2LeptinIBA
07/2012 - 10/2010
2Amyloid (Amyloid Fibrils)IBA
05/2012 - 01/2006
1Sorafenib (BAY 43-9006)FDA Link
01/2019
1Phosphotransferases (Kinase)IBA
01/2019
1Acetyl Coenzyme A (Acetyl-CoA)IBA
01/2017
1ND-646IBA
10/2016
1Carboplatin (JM8)FDA LinkGeneric
10/2016
1ND-630IBA
03/2016
1Interleukin-6 (Interleukin 6)IBA
07/2012
1ResistinIBA
07/2012
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2012
1CarbohydratesIBA
07/2012
1AdipokinesIBA
07/2012
1Retinol-Binding Proteins (Retinoid Binding Proteins)IBA
07/2012
1Biomarkers (Surrogate Marker)IBA
05/2012
1Reactive Oxygen Species (Oxygen Radicals)IBA
08/2011
1MetalsIBA
08/2011
1IronIBA
08/2011
1Streptozocin (Streptozotocin)FDA Link
08/2011
1Superoxides (Superoxide)IBA
08/2011
1Proteins (Proteins, Gene)FDA Link
08/2011
1lipoprotein cholesterolIBA
08/2011
11- (7- (2- chlorophenyl)- 8- (4- chlorophenyl)- 2- methylpyrazolo(1,5- a)(1,3,5)triazin- 4- yl)- 3- (methylamino)azetidine- 3- carboxamideIBA
10/2010
1HDL CholesterolIBA
06/2010
1EstersIBA
06/2010
1Carboxylic AcidsIBA
06/2010
1C-Reactive ProteinIBA
06/2010
1ApolipoproteinsIBA
06/2010
13- (3- (1- carboxy- 1- methylethoxy)phenyl)piperidine- 1- carboxylic acid 4-trifluoromethylbenzyl esterIBA
06/2010
1Triglycerides (Triacylglycerol)IBA
06/2010
1Apolipoprotein A-I (Apolipoprotein A1)IBA
06/2010
1PPAR alphaIBA
06/2010
1PPAR gammaIBA
06/2010
1piperidineIBA
06/2010
1Farnesyl-Diphosphate Farnesyltransferase (Squalene Synthase)IBA
02/2008
1SterolsIBA
02/2008
1G(M3) GangliosideIBA
02/2008
1Hypoglycemic Agents (Hypoglycemics)IBA
03/2005
1CP-346086IBA
10/2003
1Malonyl Coenzyme A (Malonyl CoA)IBA
09/2003
1CP-640186IBA
09/2003
1LDL Lipoproteins (beta Lipoproteins)IBA
07/2002
1LDL CholesterolIBA
07/2002

Therapy/Procedure

2Therapeutics
06/2010 - 03/2007
1Glycemic Control
06/2010